Phyrexian Unlife

You don't lose the game for having 0 or less life.
As long as you have 0 or less life, all damage is dealt to you as though its source had infect. (Damage is dealt to you in the form of poison counters.)

"While the realm's great minds quarreled over the strange eclipse, Locthwain fell to the invaders."
—*Last Stand of the Realm*

Wilds of Eldraine: Enchanting Tales

Secret Lair Drop

New Phyrexia

If you’re at 0 or less life and Phyrexian Unlife leaves the battlefield, you’ll lose the game (unless some other effect is keeping you from losing).

If you’re at 0 or less life, you can’t pay any amount of life except 0.

Phyrexian Unlife won’t affect damage that reduces your life total from a positive number to 0 or less. For example, if you’re at 3 life and are dealt 5 damage, you’ll end up at -2 life. The next time you’re dealt damage, it will be dealt as though its source had infect.

You can still lose the game for other reasons, including having ten or more poison counters or drawing a card from a library with no cards in it.