Certain Death

Destroy target creature. Its controller loses 2 life and you gain 2 life.

Shadows over Innistrad Remastered

Some spirits cling to one person, feasting on the growing fear until a final moment of all-consuming terror.

Jumpstart 2022

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Welcome Deck 2017

Eldritch Moon

If the creature becomes an illegal target for Certain Death, no player gains or loses life. If it’s a legal target but isn’t destroyed, most likely due to having indestructible, its controller still loses 2 life and you gain 2 life.

The targeted creature will have already left the battlefield before its controller loses 2 life and you gain 2 life. If it has any abilities that care about gaining or losing life, they won’t apply.