"This is what glory looks like."
—Nicol Bolas

Neheb, the Eternal

Afflict 3 (Whenever this creature becomes blocked, defending player loses 3 life.)
At the beginning of each of your postcombat main phases, add {R} for each 1 life your opponents have lost this turn.

Murders at Karlov Manor Commander

Afflict 3 (Whenever this creature becomes blocked, defending player loses 3 life.)
At the beginning of your postcombat main phase, add {R} for each 1 life your opponents have lost this turn.

Commander Masters

"Live an exemplary life. Die a worthy death. Rise in eternal glory."

Afflict causes the defending player to lose life; it's not damage or combat damage.

Afflict resolves before combat damage is dealt. If this loss of life brings a player to 0 life or less, that player loses the game immediately. A blocking creature with lifelink won't deal combat damage in time to save that player.

Because it triggers at the beginning of a phase, Neheb's last ability isn't a mana ability. It uses the stack and can be countered by effects that interact with triggered abilities, such as that of Nimble Obstructionist.

Damage dealt to a player causes that player to lose that much life.

If an opponent loses life and subsequently loses the game before your postcombat main phase, Neheb's last ability counts that loss of life.

If an opponent loses life but Neheb leaves the battlefield before your postcombat main phase begins, its last ability doesn't trigger.

If multiple creatures block a creature with afflict, afflict triggers only once.

If you somehow have more than two main phases in a turn, each main phase after your first one is a postcombat main phase, and Neheb's last ability triggers at the beginning of each of them.

Neheb's ability checks only how much life opponents lost during the turn, not by how much their life total decreased compared to the start of the turn. For example, if an opponent lost 2 life and then gained 8 life before your postcombat main phase, you'll add {R}{R}.

You get a postcombat main phase even if no creatures attacked during a turn. Neheb's last ability will trigger.

If a creature is attacking a planeswalker, that planeswalker's controller is the defending player. If a creature is attacking a battle, that battle's protector is the defending player.